The α-Helical Structure of Prodomains Promotes Translocation of Intrinsically Disordered Neuropeptide Hormones into the Endoplasmic Reticulum

Different neuropeptide hormones, which are either too small to adopt a stable conformation or are predicted to be intrinsically disordered, are synthesized as larger precursors containing a prodomain in addition to an N-terminal signal peptide. We analyzed the biogenesis of three unstructured neurop...

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Detalhes bibliográficos
Main Authors: Dirndorfer, Daniela, Seidel, Ralf P., Nimrod, Guy, Miesbauer, Margit, Ben-Tal, Nir, Engelhard, Martin, Zimmermann, Richard, Winklhofer, Konstanze F., Tatzelt, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656256/
https://ncbi.nlm.nih.gov/pubmed/23532840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430264
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