The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

Formation of aberrant protein conformers is a common pathological denominator of different neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover, increasing evidence indicates that soluble oligomers are associated with early pathological alterations and that oligo...

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Main Authors: Resenberger, Ulrike K, Harmeier, Anja, Woerner, Andreas C, Goodman, Jessica L, Müller, Veronika, Krishnan, Rajaraman, Vabulas, R Martin, Kretzschmar, Hans A, Lindquist, Susan, Hartl, F Ulrich, Multhaup, Gerd, Winklhofer, Konstanze F, Tatzelt, Jörg
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098494/
https://ncbi.nlm.nih.gov/pubmed/21441896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.86
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