The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

Formation of aberrant protein conformers is a common pathological denominator of different neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover, increasing evidence indicates that soluble oligomers are associated with early pathological alterations and that oligo...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Resenberger, Ulrike K, Harmeier, Anja, Woerner, Andreas C, Goodman, Jessica L, Müller, Veronika, Krishnan, Rajaraman, Vabulas, R Martin, Kretzschmar, Hans A, Lindquist, Susan, Hartl, F Ulrich, Multhaup, Gerd, Winklhofer, Konstanze F, Tatzelt, Jörg
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2011
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098494/
https://ncbi.nlm.nih.gov/pubmed/21441896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.86
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