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Chemical chaperones interfere with the formation of scrapie prion protein.

The fundamental event in prion diseases involves a conformational change in one or more of the alpha-helices of the cellular prion protein (PrP(C)) as they are converted into beta-sheets during the formation of the pathogenic isoform (PrP(Sc)). Here, we show that exposure of scrapie-infected mouse n...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Tatzelt, J, Prusiner, S B, Welch, W J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452460/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8978663/
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