Llwytho...

Chemical chaperones interfere with the formation of scrapie prion protein.

The fundamental event in prion diseases involves a conformational change in one or more of the alpha-helices of the cellular prion protein (PrP(C)) as they are converted into beta-sheets during the formation of the pathogenic isoform (PrP(Sc)). Here, we show that exposure of scrapie-infected mouse n...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Tatzelt, J, Prusiner, S B, Welch, W J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 1996
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452460/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8978663/
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!