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Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.

To investigate the molecular basis of prion diversity, we inoculated transgenic mice expressing the Syrian hamster prion protein (PrP) with three distinct prion isolates. We compared the three isolates designated Sc237, 139H, and Me7H in Tg(SHaPrP)7 mice with clinical signs of scrapie because the in...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: DeArmond, S J, Yang, S L, Lee, A, Bowler, R, Taraboulos, A, Groth, D, Prusiner, S B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46949/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8101989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6449
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