Doxycycline control of prion protein transgene expression modulates prion disease in mice

Conversion of the cellular prion protein (PrP(C)) into the pathogenic isoform (PrP(Sc)) is the fundamental event underlying transmission and pathogenesis of prion diseases. To control the expression of PrP(C) in transgenic (Tg) mice, we used a tetracycline controlled transactivator (tTA) driven by t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tremblay, Patrick, Meiner, Zeev, Galou, Maria, Heinrich, Cornelia, Petromilli, Chris, Lisse, Thomas, Cayetano, Juliana, Torchia, Marilyn, Mobley, William, Bujard, Hermann, DeArmond, Stephen J., Prusiner, Stanley B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22873/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770528/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12580
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