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Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.

Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To investigate prion diversity, we inoculated three "strains" of prions into congenic and transgenic mice harboring variable numbers of two differe...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Carlson, G A, Ebeling, C, Yang, S L, Telling, G, Torchia, M, Groth, D, Westaway, D, DeArmond, S J, Prusiner, S B
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1994
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44062/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7911243/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.12.5690
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