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Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans

There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(BoPrP)...

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Auteurs principaux: Scott, Michael R., Will, Robert, Ironside, James, Nguyen, Hoang-Oanh B., Tremblay, Patrick, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC24786/
https://ncbi.nlm.nih.gov/pubmed/10611351
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