Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans

There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(BoPrP)...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Scott, Michael R., Will, Robert, Ironside, James, Nguyen, Hoang-Oanh B., Tremblay, Patrick, DeArmond, Stephen J., Prusiner, Stanley B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.26.15137
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