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Doxycycline control of prion protein transgene expression modulates prion disease in mice
Conversion of the cellular prion protein (PrP(C)) into the pathogenic isoform (PrP(Sc)) is the fundamental event underlying transmission and pathogenesis of prion diseases. To control the expression of PrP(C) in transgenic (Tg) mice, we used a tetracycline controlled transactivator (tTA) driven by t...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
1998
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC22873/ https://ncbi.nlm.nih.gov/pubmed/9770528 |
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