Doxycycline control of prion protein transgene expression modulates prion disease in mice

Conversion of the cellular prion protein (PrP(C)) into the pathogenic isoform (PrP(Sc)) is the fundamental event underlying transmission and pathogenesis of prion diseases. To control the expression of PrP(C) in transgenic (Tg) mice, we used a tetracycline controlled transactivator (tTA) driven by t...

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Autores principales: Tremblay, Patrick, Meiner, Zeev, Galou, Maria, Heinrich, Cornelia, Petromilli, Chris, Lisse, Thomas, Cayetano, Juliana, Torchia, Marilyn, Mobley, William, Bujard, Hermann, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC22873/
https://ncbi.nlm.nih.gov/pubmed/9770528
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