Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the APP GxxxG Motif

The identification of hereditary familial Alzheimer disease (FAD) mutations in the amyloid precursor protein (APP) and presenilin-1 (PS1) corroborated the causative role of amyloid-β peptides with 42 amino acid residues (Aβ42) in the pathogenesis of AD. Although most FAD mutations are known to incre...

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Main Authors: Munter, Lisa-Marie, Botev, Anne, Richter, Luise, Hildebrand, Peter W., Althoff, Veit, Weise, Christoph, Kaden, Daniela, Multhaup, Gerd
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898405/
https://ncbi.nlm.nih.gov/pubmed/20452985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088005
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