GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

Processing of the amyloid precursor protein (APP) by β- and γ-secretases leads to the generation of amyloid-β (Aβ) peptides with varying lengths. Particularly Aβ42 contributes to cytotoxicity and amyloid accumulation in Alzheimer's disease (AD). However, the precise molecular mechanism of Aβ42...

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Hlavní autoři: Munter, Lisa-Marie, Voigt, Philipp, Harmeier, Anja, Kaden, Daniela, Gottschalk, Kay E, Weise, Christoph, Pipkorn, Rüdiger, Schaefer, Michael, Langosch, Dieter, Multhaup, Gerd
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829382/
https://ncbi.nlm.nih.gov/pubmed/17332749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601616
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