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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42
Processing of the amyloid precursor protein (APP) by β- and γ-secretases leads to the generation of amyloid-β (Aβ) peptides with varying lengths. Particularly Aβ42 contributes to cytotoxicity and amyloid accumulation in Alzheimer's disease (AD). However, the precise molecular mechanism of Aβ42...
Gorde:
| Egile Nagusiak: | , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2007
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1829382/ https://ncbi.nlm.nih.gov/pubmed/17332749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601616 |
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