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Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers
Here, we describe a novel missense mutation in the amyloid precursor protein (APP) causing a lysine-to-asparagine substitution at position 687 (APP770; herein, referred to as K16N according to amyloid-β (Aβ) numbering) resulting in an early onset dementia with an autosomal dominant inheritance patte...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3407951/ https://ncbi.nlm.nih.gov/pubmed/22514144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200239 |
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