Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions

Processing of the amyloid precursor protein (APP) by γ-secretase results in generation of Aβ peptides of different lengths ranging from 51 to 30 residues. Accumulation of Aβ and in particular Aβ42 is enhanced by familial Alzheimer disease (FAD) causing mutations in APP and is believed to play a pivo...

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Detalhes bibliográficos
Main Authors: Olsson, Fredrik, Schmidt, Staffan, Althoff, Veit, Munter, Lisa M., Jin, Shaobo, Rosqvist, Susanne, Lendahl, Urban, Multhaup, Gerd, Lundkvist, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894335/
https://ncbi.nlm.nih.gov/pubmed/24225948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498246
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