The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to understand the processing of the amyloid precursor protein (APP) is of critical importance. Recently, we demonstrated that t...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bien, Jessica, Jefferson, Tamara, Čaušević, Mirsada, Jumpertz, Thorsten, Munter, Lisa, Multhaup, Gerd, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460434/
https://ncbi.nlm.nih.gov/pubmed/22879596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395608
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