The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to understand the processing of the amyloid precursor protein (APP) is of critical importance. Recently, we demonstrated that t...

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Bibliographische Detailangaben
Hauptverfasser: Bien, Jessica, Jefferson, Tamara, Čaušević, Mirsada, Jumpertz, Thorsten, Munter, Lisa, Multhaup, Gerd, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460434/
https://ncbi.nlm.nih.gov/pubmed/22879596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395608
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