Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

BACKGROUND: The metalloprotease meprin β cleaves the Alzheimer’s Disease (AD) relevant amyloid precursor protein (APP) as a β-secretase reminiscent of BACE-1, however, predominantly generating N-terminally truncated Aβ2-x variants. RESULTS: Herein, we observed increased endogenous sAPPα levels in th...

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Pubblicato in:Mol Neurodegener
Autori principali: Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Wichert, Rielana, Prox, Johannes, Altmeppen, Hermann, Kumar, Sathish, Walter, Jochen, Lichtenthaler, Stefan F., Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759862/
https://ncbi.nlm.nih.gov/pubmed/26895626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0084-5
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