The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

The in vivo roles of meprin metalloproteases in pathophysiological conditions remain elusive. Substrates define protease roles. Therefore, to identify natural substrates for human meprin α and β we employed TAILS (terminal amine isotopic labeling of substrates), a proteomics approach that enriches f...

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Main Authors: Jefferson, Tamara, auf dem Keller, Ulrich, Bellac, Caroline, Metz, Verena V., Broder, Claudia, Hedrich, Jana, Ohler, Anke, Maier, Wladislaw, Magdolen, Viktor, Sterchi, Erwin, Bond, Judith S., Jayakumar, Arumugam, Traupe, Heiko, Chalaris, Athena, Rose-John, Stefan, Pietrzik, Claus U., Postina, Rolf, Overall, Christopher M., Becker-Pauly, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: SP Birkhäuser Verlag Basel 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535375/
https://ncbi.nlm.nih.gov/pubmed/22940918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1106-2
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