Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates

Astacins are secreted and membrane-bound metalloproteases with clear associations to many important pathological and physiological processes. Yet with only a few substrates described their biological roles are enigmatic. Moreover, the lack of knowledge of astacin cleavage site specificities hampers...

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Detalhes bibliográficos
Main Authors: Becker-Pauly, Christoph, Barré, Olivier, Schilling, Oliver, auf dem Keller, Ulrich, Ohler, Anke, Broder, Claudia, Schütte, André, Kappelhoff, Reinhild, Stöcker, Walter, Overall, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186203/
https://ncbi.nlm.nih.gov/pubmed/21693781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.009233
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