Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

Type I fibrillar collagen is the most abundant protein in the human body, crucial for the formation and strength of bones, skin, and tendon. Proteolytic enzymes are essential for initiation of the assembly of collagen fibrils by cleaving off the propeptides. We report that Mep1a(−/−) and Mep1b(−/−)...

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Hlavní autoři: Broder, Claudia, Arnold, Philipp, Vadon-Le Goff, Sandrine, Konerding, Moritz A., Bahr, Kerstin, Müller, Stefan, Overall, Christopher M., Bond, Judith S., Koudelka, Tomas, Tholey, Andreas, Hulmes, David J. S., Moali, Catherine, Becker-Pauly, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761563/
https://ncbi.nlm.nih.gov/pubmed/23940311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305464110
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