Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1

Procollagen C-proteinase enhancer-1 (PCPE-1) is a secreted protein that specifically accelerates proteolytic release of the C-propeptides from fibrillar procollagens, a crucial step in fibril assembly. As such, it is a potential therapeutic target to improve tissue repair and prevent fibrosis, a maj...

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Bibliographische Detailangaben
Veröffentlicht in:Structure
Hauptverfasser: Pulido, David, Sharma, Urvashi, Vadon-Le Goff, Sandrine, Hussain, Sadaf-Ahmahni, Cordes, Sarah, Mariano, Natacha, Bettler, Emmanuel, Moali, Catherine, Aghajari, Nushin, Hohenester, Erhard, Hulmes, David J.S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372009/
https://ncbi.nlm.nih.gov/pubmed/30078642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.06.011
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