Strong Cooperativity and Loose Geometry between CUB Domains Are the Basis for Procollagen C-Proteinase Enhancer Activity

Procollagen C-proteinase enhancers (PCPE-1 and -2) specifically activate bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family during C-terminal processing of fibrillar collagen precursors. PCPEs consist of two CUB domains (CUB1 and CUB2) and one NTR domain separate...

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Autores principales: Kronenberg, Daniel, Vadon-Le Goff, Sandrine, Bourhis, Jean-Marie, Font, Bernard, Eichenberger, Denise, Hulmes, David J. S., Moali, Catherine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785188/
https://ncbi.nlm.nih.gov/pubmed/19801683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046128
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