The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

The in vivo roles of meprin metalloproteases in pathophysiological conditions remain elusive. Substrates define protease roles. Therefore, to identify natural substrates for human meprin α and β we employed TAILS (terminal amine isotopic labeling of substrates), a proteomics approach that enriches f...

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Bibliografiske detaljer
Main Authors: Jefferson, Tamara, auf dem Keller, Ulrich, Bellac, Caroline, Metz, Verena V., Broder, Claudia, Hedrich, Jana, Ohler, Anke, Maier, Wladislaw, Magdolen, Viktor, Sterchi, Erwin, Bond, Judith S., Jayakumar, Arumugam, Traupe, Heiko, Chalaris, Athena, Rose-John, Stefan, Pietrzik, Claus U., Postina, Rolf, Overall, Christopher M., Becker-Pauly, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: SP Birkhäuser Verlag Basel 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535375/
https://ncbi.nlm.nih.gov/pubmed/22940918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1106-2
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