The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

The in vivo roles of meprin metalloproteases in pathophysiological conditions remain elusive. Substrates define protease roles. Therefore, to identify natural substrates for human meprin α and β we employed TAILS (terminal amine isotopic labeling of substrates), a proteomics approach that enriches f...

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書誌詳細
主要な著者: Jefferson, Tamara, auf dem Keller, Ulrich, Bellac, Caroline, Metz, Verena V., Broder, Claudia, Hedrich, Jana, Ohler, Anke, Maier, Wladislaw, Magdolen, Viktor, Sterchi, Erwin, Bond, Judith S., Jayakumar, Arumugam, Traupe, Heiko, Chalaris, Athena, Rose-John, Stefan, Pietrzik, Claus U., Postina, Rolf, Overall, Christopher M., Becker-Pauly, Christoph
フォーマット: Artigo
言語:Inglês
出版事項: SP Birkhäuser Verlag Basel 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535375/
https://ncbi.nlm.nih.gov/pubmed/22940918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1106-2
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