The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

The in vivo roles of meprin metalloproteases in pathophysiological conditions remain elusive. Substrates define protease roles. Therefore, to identify natural substrates for human meprin α and β we employed TAILS (terminal amine isotopic labeling of substrates), a proteomics approach that enriches f...

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Hlavní autoři: Jefferson, Tamara, auf dem Keller, Ulrich, Bellac, Caroline, Metz, Verena V., Broder, Claudia, Hedrich, Jana, Ohler, Anke, Maier, Wladislaw, Magdolen, Viktor, Sterchi, Erwin, Bond, Judith S., Jayakumar, Arumugam, Traupe, Heiko, Chalaris, Athena, Rose-John, Stefan, Pietrzik, Claus U., Postina, Rolf, Overall, Christopher M., Becker-Pauly, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: SP Birkhäuser Verlag Basel 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535375/
https://ncbi.nlm.nih.gov/pubmed/22940918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1106-2
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