Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

The β-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Aβ peptides, which have been implicated as central players in the pathology of Alzheimer disease. BACE1 has been described as a copper-binding protein and its oligomeric state as being monomeric, dimeric, and/or...

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Publicado en:J Biol Chem
Autores principales: Liebsch, Filip, Aurousseau, Mark R. P., Bethge, Tobias, McGuire, Hugo, Scolari, Silvia, Herrmann, Andreas, Blunck, Rikard, Bowie, Derek, Multhaup, Gerd
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555187/
https://ncbi.nlm.nih.gov/pubmed/28637867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.779165
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