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APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding
Regulated intramembrane proteolysis of the amyloid precursor protein (APP) and its homologs, the APP like proteins APLP1 and APLP2, is typically a two-step process, which is initiated by ectodomain-shedding of the substrates by α- or β-secretases. Growing evidence, however, indicates that the cleava...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5789831/ https://ncbi.nlm.nih.gov/pubmed/29382944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19530-8 |
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