Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization

The amyloid precursor protein (APP) and the APP-like proteins 1 and 2 (APLP1 and APLP2) are a family of multidomain transmembrane proteins possessing homo- and heterotypic contact sites in their ectodomains. We previously reported that divalent metal ions dictate the conformation of the extracellula...

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Detalhes bibliográficos
Main Authors: Mayer, Magnus C., Kaden, Daniela, Schauenburg, Linda, Hancock, Mark A., Voigt, Philipp, Roeser, Dirk, Barucker, Christian, Than, Manuel E., Schaefer, Michael, Multhaup, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081940/
https://ncbi.nlm.nih.gov/pubmed/24855651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570382
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