Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

Presenilin 1 (PS1), presenilin 2, and nicastrin form high molecular weight complexes that are necessary for the endoproteolysis of several type 1 transmembrane proteins, including amyloid precursor protein (APP) and the Notch receptor, by apparently similar mechanisms. The cleavage of the Notch rece...

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Bibliografiske detaljer
Main Authors: Rozmahel, Richard, Mount, Howard T. J., Chen, Fusheng, Nguyen, Van, Huang, Jean, Erdebil, Serap, Liauw, Jennifer, Yu, Gang, Hasegawa, Hiroshe, Gu, YongJun, Song, You-Qiang, Schmidt, Stephen D., Nixon, Ralph A., Mathews, Paul M., Bergeron, Catherine, Fraser, Paul, Westaway, David, St George-Hyslop, Peter
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137904/
https://ncbi.nlm.nih.gov/pubmed/12388777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222413999
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