Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

Presenilin 1 (PS1), presenilin 2, and nicastrin form high molecular weight complexes that are necessary for the endoproteolysis of several type 1 transmembrane proteins, including amyloid precursor protein (APP) and the Notch receptor, by apparently similar mechanisms. The cleavage of the Notch rece...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Rozmahel, Richard, Mount, Howard T. J., Chen, Fusheng, Nguyen, Van, Huang, Jean, Erdebil, Serap, Liauw, Jennifer, Yu, Gang, Hasegawa, Hiroshe, Gu, YongJun, Song, You-Qiang, Schmidt, Stephen D., Nixon, Ralph A., Mathews, Paul M., Bergeron, Catherine, Fraser, Paul, Westaway, David, St George-Hyslop, Peter
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2002
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137904/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12388777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222413999
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

Podobné jednotky