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The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
γ-Secretase is an intramembrane cleaving protease involved in Alzheimer's disease. γ-Secretase occurs as a high molecular weight complex composed of presenilin (PS1/2), nicastrin (NCT), anterior pharynx-defective phenotype 1 and PS enhancer 2. Little is known about the cellular mechanisms of γ-...
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| Izdano u: | EMBO J |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2004
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15549135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600478 |
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