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Polar Transmembrane-based Amino Acids in Presenilin 1 Are Involved in Endoplasmic Reticulum Localization, Pen2 Protein Binding, and γ-Secretase Complex Stabilization

γ-Secretase is composed of the four membrane proteins presenilin, nicastrin, Pen2, and Aph1. These four proteins assemble in a coordinated and regulated manner into a high molecular weight complex. The subunits constitute a total of 19 transmembrane domains (TMD), with many carrying important amino...

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Detalhes bibliográficos
Main Authors: Fassler, Matthias, Li, Xiaolin, Kaether, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207410/
https://ncbi.nlm.nih.gov/pubmed/21914807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252429
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