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Polar Transmembrane-based Amino Acids in Presenilin 1 Are Involved in Endoplasmic Reticulum Localization, Pen2 Protein Binding, and γ-Secretase Complex Stabilization
γ-Secretase is composed of the four membrane proteins presenilin, nicastrin, Pen2, and Aph1. These four proteins assemble in a coordinated and regulated manner into a high molecular weight complex. The subunits constitute a total of 19 transmembrane domains (TMD), with many carrying important amino...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207410/ https://ncbi.nlm.nih.gov/pubmed/21914807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252429 |
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