Possible Mechanisms of Action of NSAIDs and Related Compounds that Modulate γ-Secretase Cleavage

Por Kukar, Thomas, Golde, Todd E.
Publicado em 2008

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations

Por Holler, Christopher J., Taylor, Georgia, Deng, Qiudong, Kukar, Thomas
Publicado no eNeuro (2017)

Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity

Por Ghag, Gaurav, Holler, Christopher J., Taylor, Georgia, Kukar, Thomas L., Uversky, Vladimir N., Rangachari, Vijayaraghavan
Publicado no Protein Sci (2017)

An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()

Por Frigerio, Carlo Sala, Kukar, Thomas L., Fauq, Abdul, Engel, Paul C., Golde, Todd E., Walsh, Dominic M.
Publicado no Biochemistry (2009)

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

Por Kukar, Thomas, Prescott, Sonya, Eriksen, Jason L, Holloway, Vallie, Murphy, M Paul, Koo, Edward H, Golde, Todd E, Nicolle, Michelle M
Publicado em 2007

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

Por Das, Pritam, Verbeeck, Christophe, Minter, Lisa, Chakrabarty, Paramita, Felsenstein, Kevin, Kukar, Thomas, Maharvi, Ghulam, Fauq, Abdul, Osborne, Barbara A, Golde, Todd E
Publicado em 2012

Steroids as γ-secretase modulators

Por Jung, Joo In, Ladd, Thomas B., Kukar, Thomas, Price, Ashleigh R., Moore, Brenda D., Koo, Edward H., Golde, Todd E., Felsenstein, Kevin M.
Publicado em 2013

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

Por Sagi, Sarah A., Lessard, Christian B., Winden, Kellen D., Maruyama, Hiroko, Koo, Jeremy C., Weggen, Sascha, Kukar, Thomas L., Golde, Todd E., Koo, Edward H.
Publicado em 2011

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

Por Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Publicado em 2014

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

Por Verbeeck, Christophe, Deng, Qiudong, DeJesus-Hernandez, Mariely, Taylor, Georgia, Ceballos-Diaz, Carolina, Kocerha, Jannet, Golde, Todd, Das, Pritam, Rademakers, Rosa, Dickson, Dennis W, Kukar, Thomas
Publicado em 2012

FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

Por Deng, Qiudong, Holler, Christopher J., Taylor, Georgia, Hudson, Kathryn F., Watkins, William, Gearing, Marla, Ito, Daisuke, Murray, Melissa E., Dickson, Dennis W., Seyfried, Nicholas T., Kukar, Thomas
Publicado em 2014

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

Por Holler, Christopher J., Taylor, Georgia, McEachin, Zachary T., Deng, Qiudong, Watkins, William J., Hudson, Kathryn, Easley, Charles A., Hu, William T., Hales, Chadwick M., Rossoll, Wilfried, Bassell, Gary J., Kukar, Thomas
Publicado no Mol Neurodegener (2016)

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

Por Chen, Xi, Chang, Jianjun, Deng, Qiudong, Xu, Jie, Nguyen, Thi A., Martens, Lauren H., Cenik, Basar, Taylor, Georgia, Hudson, Kathryn F., Chung, Jaegwon, Yu, Kimberley, Yu, Phillip, Herz, Joachim, Farese, Robert V., Kukar, Thomas, Tansey, Malú G.
Publicado em 2013

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length: SUPPORT FOR A SEQUENTIAL MODEL OF γ-SECRETASE INTRAMEMBRANE PROTEOLYSIS AND...

Por Kukar, Thomas L., Ladd, Thomas B., Robertson, Paul, Pintchovski, Sean A., Moore, Brenda, Bann, Maralyssa A., Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A., Das, Pritam, Basi, Guriqbal S., Koo, Edward H., Golde, Todd E.
Publicado em 2011

Short Aβ peptides attenuate Aβ42 toxicity in vivo

Por Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Publicado no J Exp Med (2018)

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

Por Chou, Ching-Chieh, Zhang, Yi, Umoh, Mfon E., Vaughan, Spencer W., Lorenzini, Ileana, Liu, Feilin, Sayegh, Melissa, Donlin-Asp, Paul G., Chen, Yu Han, Duong, Duc M., Seyfried, Nicholas T., Powers, Maureen A., Kukar, Thomas, Hales, Chadwick M., Gearing, Marla, Cairns, Nigel J., Boylan, Kevin B., Dickson, Dennis W., Rademakers, Rosa, Zhang, Yong-Jie, Petrucelli, Leonard, Sattler, Rita, Zarnescu, Daniela C., Glass, Jonathan D., Rossoll, Wilfried
Publicado no Nat Neurosci (2018)

Substrate-targeting γ-secretase modulators

Por Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.
Publicado em 2008