Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

Eitemau Tebyg

• γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
  gan: Christian B Lessard, et al.
  Cyhoeddwyd: (2015-01-01)
• γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
  gan: Lessard, Christian B., et al.
  Cyhoeddwyd: (2015)
• Formation of Pmel17 Amyloid Is Regulated by Juxtamembrane Metalloproteinase Cleavage, and the Resulting C-terminal Fragment Is a Substrate for γ-Secretase
  gan: Kummer, Markus P., et al.
  Cyhoeddwyd: (2009)
• An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()
  gan: Frigerio, Carlo Sala, et al.
  Cyhoeddwyd: (2009)
• Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
  gan: Jung, Joo In, et al.
  Cyhoeddwyd: (2014)