An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()

Inhibition of γ-secretase cleavage of the amyloid precursor protein (APP) is a prime target for the development of therapeutics for treating Alzheimer’s disease; however, complete inhibition of this activity would also impair the processing of many other proteins, including the APP homologues, amylo...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Frigerio, Carlo Sala, Kukar, Thomas L., Fauq, Abdul, Engel, Paul C., Golde, Todd E., Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489158/
https://ncbi.nlm.nih.gov/pubmed/19821615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901237k
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