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An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()

Inhibition of γ-secretase cleavage of the amyloid precursor protein (APP) is a prime target for the development of therapeutics for treating Alzheimer’s disease; however, complete inhibition of this activity would also impair the processing of many other proteins, including the APP homologues, amylo...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Biochemistry
Päätekijät: Frigerio, Carlo Sala, Kukar, Thomas L., Fauq, Abdul, Engel, Paul C., Golde, Todd E., Walsh, Dominic M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489158/
https://ncbi.nlm.nih.gov/pubmed/19821615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901237k
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