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Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein
Proteolytic processing of the amyloid precursor protein (APP) by β-secretase, β-site APP cleaving enzyme (BACE1), is the initial step in the production of the amyloid β (Aβ) peptide, which is involved in the pathogenesis of Alzheimer's disease. The normal cellular function of the prion protein...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2007
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904148/ https://ncbi.nlm.nih.gov/pubmed/17573534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609621104 |
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