Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein

Proteolytic processing of the amyloid precursor protein (APP) by β-secretase, β-site APP cleaving enzyme (BACE1), is the initial step in the production of the amyloid β (Aβ) peptide, which is involved in the pathogenesis of Alzheimer's disease. The normal cellular function of the prion protein...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Parkin, Edward T., Watt, Nicole T., Hussain, Ishrut, Eckman, Elizabeth A., Eckman, Christopher B., Manson, Jean C., Baybutt, Herbert N., Turner, Anthony J., Hooper, Nigel M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2007
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904148/
https://ncbi.nlm.nih.gov/pubmed/17573534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609621104
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk