Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein

In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ. We have reported previously that the cellular prion protein (PrP(C)) inhibited the action...

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Detalhes bibliográficos
Main Authors: Griffiths, Heledd H., Whitehouse, Isobel J., Baybutt, Herbert, Brown, Debbie, Kellett, Katherine A. B., Jackson, Carolyn D., Turner, Anthony J., Piccardo, Pedro, Manson, Jean C., Hooper, Nigel M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190950/
https://ncbi.nlm.nih.gov/pubmed/21795680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.278556
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