Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype

The cellular prion protein (PrP(C)) has been proposed to play an important role in the pathogenesis of Alzheimer’s disease. In cellular models PrP(C) inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a reduction in amyloid-β (Aβ) peptides. Here we have...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Whitehouse, Isobel J., Brown, Deborah, Baybutt, Herbert, Diack, Abigail B., Kellett, Katherine A. B., Piccardo, Pedro, Manson, Jean C., Hooper, Nigel M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957828/
https://ncbi.nlm.nih.gov/pubmed/27447728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159119
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