Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity

Por Ghag, Gaurav, Holler, Christopher J., Taylor, Georgia, Kukar, Thomas L., Uversky, Vladimir N., Rangachari, Vijayaraghavan
Publicado no Protein Sci (2017)

An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()

Por Frigerio, Carlo Sala, Kukar, Thomas L., Fauq, Abdul, Engel, Paul C., Golde, Todd E., Walsh, Dominic M.
Publicado no Biochemistry (2009)

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

Por Sagi, Sarah A., Lessard, Christian B., Winden, Kellen D., Maruyama, Hiroko, Koo, Jeremy C., Weggen, Sascha, Kukar, Thomas L., Golde, Todd E., Koo, Edward H.
Publicado em 2011

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

Por Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Publicado em 2014

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length: SUPPORT FOR A SEQUENTIAL MODEL OF γ-SECRETASE INTRAMEMBRANE PROTEOLYSIS AND...

Por Kukar, Thomas L., Ladd, Thomas B., Robertson, Paul, Pintchovski, Sean A., Moore, Brenda, Bann, Maralyssa A., Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A., Das, Pritam, Basi, Guriqbal S., Koo, Edward H., Golde, Todd E.
Publicado em 2011

Short Aβ peptides attenuate Aβ42 toxicity in vivo

Por Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Publicado no J Exp Med (2018)

Substrate-targeting γ-secretase modulators

Por Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.
Publicado em 2008