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Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
[Image: see text] γ-Secretase catalyzes the final cleavage of the amyloid precursor protein (APP), resulting in the production of amyloid-β (Aβ) peptides with different carboxyl termini. Presenilin (PSEN) and amyloid precursor protein (APP) mutations linked to early onset familial Alzheimer’s diseas...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985764/ https://ncbi.nlm.nih.gov/pubmed/24620716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401521t |
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