Short Aβ peptides attenuate Aβ42 toxicity in vivo

Processing of amyloid-β (Aβ) precursor protein (APP) by γ-secretase produces multiple species of Aβ: Aβ40, short Aβ peptides (Aβ37–39), and longer Aβ peptides (Aβ42–43). γ-Secretase modulators, a class of Alzheimer’s disease therapeutics, reduce production of the pathogenic Aβ42 but increase the rel...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748850/
https://ncbi.nlm.nih.gov/pubmed/29208777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170600
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