Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length: SUPPORT FOR A SEQUENTIAL MODEL OF γ-SECRETASE INTRAMEMBRANE PROTEOLYSIS AND REGULATION BY THE AMYLOID β PRECURSOR PROTEIN (APP) JUXTAMEMBRANE REGION

γ-Secretase is a multiprotein intramembrane cleaving aspartyl protease (I-CLiP) that catalyzes the final cleavage of the amyloid β precursor protein (APP) to release the amyloid β peptide (Aβ). Aβ is the primary component of senile plaques in Alzheimer's disease (AD), and its mechanism of produ...

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Dades bibliogràfiques
Autors principals: Kukar, Thomas L., Ladd, Thomas B., Robertson, Paul, Pintchovski, Sean A., Moore, Brenda, Bann, Maralyssa A., Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A., Das, Pritam, Basi, Guriqbal S., Koo, Edward H., Golde, Todd E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220543/
https://ncbi.nlm.nih.gov/pubmed/21868378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274696
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