Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

BACKGROUND: Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (GRN) are a common cause of frontotemporal lobar degeneration (FTLD) and lead to disease through PGRN haploinsufficiency....

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Udgivet i:Mol Neurodegener
Main Authors: Holler, Christopher J., Taylor, Georgia, McEachin, Zachary T., Deng, Qiudong, Watkins, William J., Hudson, Kathryn, Easley, Charles A., Hu, William T., Hales, Chadwick M., Rossoll, Wilfried, Bassell, Gary J., Kukar, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919863/
https://ncbi.nlm.nih.gov/pubmed/27341800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0114-3
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