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Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
Frontotemporal lobar degeneration with TDP- 43 inclusions (FTLD-TDP) is characterized by progressive decline in behavior, executive function, and language. Progranulin (GRN) gene mutations are pathogenic for FTLD-TDP, and GRN transcript haploinsufficiency is the proposed disease mechanism. However,...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104467/ https://ncbi.nlm.nih.gov/pubmed/19649643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-009-0576-2 |
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