Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

BACKGROUND: Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (GRN) are a common cause of frontotemporal lobar degeneration (FTLD) and lead to disease through PGRN haploinsufficiency....

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Dades bibliogràfiques
Publicat a:Mol Neurodegener
Autors principals: Holler, Christopher J., Taylor, Georgia, McEachin, Zachary T., Deng, Qiudong, Watkins, William J., Hudson, Kathryn, Easley, Charles A., Hu, William T., Hales, Chadwick M., Rossoll, Wilfried, Bassell, Gary J., Kukar, Thomas
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919863/
https://ncbi.nlm.nih.gov/pubmed/27341800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0114-3
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