Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis

Transgenic mice that express mutant amyloid precursor protein (APPsi) using tet-Off vector systems provide an alternative model for assessing short- and long-term effects of Aβ-targeting therapies on phenotypes related to the deposition of Alzheimer-type amyloid. Here we use such a model, termed APP...

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Hlavní autoři: Melnikova, Tatiana, Fromholt, Susan, Kim, HyunSu, Lee, Deidre, Xu, Guilian, Price, Ashleigh, Moore, Brenda D., Golde, Todd E., Felsenstein, Kevin M., Savonenko, Alena, Borchelt, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711622/
https://ncbi.nlm.nih.gov/pubmed/23447589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4251-12.2013
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