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Modeling an Anti-Amyloid Combination Therapy for Alzheimer's Disease

As only symptomatic treatments are now available for Alzheimer's disease (AD), safe and effective mechanism-based therapies remain a great unmet need for patients with this neurodegenerative disease. Although γ-secretase and BACE1 [β-site β-amyloid (Aβ) precursor protein (APP) cleaving enzyme 1...

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Detalhes bibliográficos
Main Authors: Chow, Vivian W., Savonenko, Alena V., Melnikova, Tatiana, Kim, Hyunsu, Price, Donald L., Li, Tong, Wong, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852193/
https://ncbi.nlm.nih.gov/pubmed/20371462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000337
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