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Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors
The signal peptide peptidases (SPPs) are biomedically important proteases implicated as therapeutic targets for hepatitis C (human SPP, (hSPP)), plasmodium (Plasmodium SPP (pSPP)), and B-cell immunomodulation and neoplasia (signal peptide peptidase like 2a, (SPPL2a)). To date, no drug-like, selectiv...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457840/ https://ncbi.nlm.nih.gov/pubmed/26046535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128619 |
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