γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

BACKGROUND: γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subtle differences in PS1- and PS2-mediated cleavages of select...

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Pubblicato in:Alzheimers Res Ther
Autori principali: Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236921/
https://ncbi.nlm.nih.gov/pubmed/32430033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00622-5
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