An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes

Hypothalamic–pituitary–adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody, CTRND05, targeting corticotropin-releasing factor (CRF). In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects...

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Vydáno v:J Exp Med
Hlavní autoři: Futch, Hunter S., McFarland, Karen N., Moore, Brenda D., Kuhn, M. Zino, Giasson, Benoit I., Ladd, Thomas B., Scott, Karen A., Shapiro, Melanie R., Nosacka, Rachel L., Goodwin, Marshall S., Ran, Yong, Cruz, Pedro E., Ryu, Daniel H., Croft, Cara L., Levites, Yona, Janus, Christopher, Chakrabarty, Paramita, Judge, Andrew R., Brusko, Todd M., de Kloet, Annette D., Krause, Eric G., Golde, Todd E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829597/
https://ncbi.nlm.nih.gov/pubmed/31467037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190430
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