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An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes
Hypothalamic–pituitary–adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody, CTRND05, targeting corticotropin-releasing factor (CRF). In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects...
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| Vydáno v: | J Exp Med |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Rockefeller University Press
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6829597/ https://ncbi.nlm.nih.gov/pubmed/31467037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190430 |
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