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Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

Progressive aggregation of alpha-synuclein (αS) through formation of amorphous pale bodies to mature Lewy bodies or in neuronal processes as Lewy neurites may be the consequence of conformational protein changes and accumulations, which structurally represents “molecular template”. Focal initiation...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Uchihara, Toshiki, Giasson, Benoit I.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698305/
https://ncbi.nlm.nih.gov/pubmed/26446103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1485-1
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