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Endogenous Oligodendroglial Alpha-Synuclein and TPPP/p25α Orchestrate Alpha-Synuclein Pathology in Experimental Multiple System Atrophy Models

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol
Hoofdauteurs: Mavroeidi, Panagiota, Arvanitaki, Fedra, Karakitsou, Anastasia-Kiriaki, Vetsi, Maria, Kloukina, Ismini, Zweckstetter, Markus, Giller, Karin, Becker, Stefan, Sorrentino, Zachary A., Giasson, Benoit I., Henning Jensen, Poul, Stefanis, Leonidas, Xilouri, Maria
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289399/
https://ncbi.nlm.nih.gov/pubmed/31011860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02014-y
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